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Maggie's shocking death destabilises the family, leading to Bart's descent deep in to the world of heroin. Meanwhile, Marge has a nervous breakdown and becomes hospitalised following an attempted murder/suicide at the Kwik-E-Mart. Faced with their family's disintegration, Homer and Lisa bond over the unlikely sport of basketball.
Have Homer framed for a crime he didn't commit, he escapes and the family is forced to go underground, becoming soldiers of fortune, helping small towns overthrow drug lords every week. Marge can develop a new catchphrase: "I an't gettin' on no plane".
Grandma Bouvier develops chronic Alzheimer's and is found one day lying in a ditch naked. Ralph Wiggum is accused of molestation, but let off after a lengthy courtroom drama that challenges the residents opinions on the personal responsibility of retarded individuals with alopecia. Lionel Hutz sums up the argument, asking whether it really matters if a spacko rapes someone who's not going to remember it anyway.
In the B plot, Homer secretly goes gay for pay after losing his job yet again. His cover is eventually blown by Kirk Van Houten.