The Pickle Jar

SuN

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This is my final post on FCF. I thought before I disappeared permanently I'd give everyone (that's interested) a final word from me.

Within less than a month, my life has become an endless downward spiral of emotional agony and hardship. About 3 weeks ago, I received an email from my college that my normally renewable $10000 scholarship will be discontinued indefinitely, just one year from graduating with my degree. I won't be able to pay for my tuition next year due to economic troubles and my lack of credit. My future is now more uncertain than it ever was.

My handicapped brother who has within the past few months developed a severe case of schizophrenia is now so drugged up he doesn't recognize his own family and will soon be institutionalized for his condition.

My great aunt recently had a stroke so severe it's rendered her comatose and very possibly on her death bed for a 79 year old woman with a history of heart problems. The prospect of attending a funeral for another relative is devastating enough.

Business at my current employment has become so ridiculously slow that I'm almost certain to be laid off within the month, especially considering my diminished work ethic over the past few days for obvious reasons. Money simply doesn't hold much value to me anymore...

Now all of these things I was sure I could have handled somehow, so long as the final straw hadn't been pulled, though it was. I'm sure by now all of you know what straw that was. It's left me depressed and inconsolable for the past several days...but even since our break up I somehow held out a last shred of hope that I could, after a time remain friends with Bex and everyone else, until today.

I've seen this thread, and with it the final blow has been dealt. I won't deny any of it, because unfortunately it is all true. A long time ago I was a very weak minded individual, paranoid and doubtful of everything. At that time I was never fully convinced that a girl as beautiful, amazing, and simply perfect as Bex was and is could ever truly love me, someone so undesirable in every way as I saw myself. I committed horrible acts; despicable, lewd, and utterly unforgivable acts of infidelity. I was a fool to think my guilt would ever be contained, as if I deserved to harbor such a disgusting secret from everyone, especially the one I loved. However, although I regretted everything I had done with the utmost disdain for myself, I knew it would be easier to live with my guilt than to have to live without her love.

Even so, it was still very hard to live with, as Channy would repeatedly blackmail me with threats of revealing everything if I didn't conform to her wishes. I felt like a slave, trapped and helpless. I tried to make peace several times to avoid it but I knew eventually the pressure would give way. I wanted to tell Bex everything myself, and end our relationship so that I wouldn't drag her along, but I was still weak, scared and selfish. I wanted to make things work because I knew I couldn't afford to lose her. She was everything to me, always.

When Channy told Bex in April of '08, I was sure my relationship was over, and the pain of heartbreak began to set in. However, Channy left out certain points, and Bex not realizing how seriously I had disgraced her, for reasons not entirely clear, remained with me. I knew I was not deserving of her continued friendship let alone love, but it was granted to me as if by some miracle of fate. With our relationship still intact, I made a vow to her and myself to devote my life to her happiness. I knew I could never erase the past, but I hoped to build a brighter future and be the absolute best man any woman could ever ask for, because Bex deserved nothing less than that. Over the next 10 months I spent thousands of dollars to travel to England to see her, bought her expensive jewelery as thoughtful gifts always personalizing my love to her through them, spent countless hours making sure I was available to her whenever she needed me, devoting every minute I was online to her, listening and consoling and advising and loving her. I knew in my heart she loved me, and that was all I needed to give my 100% to hear everyday. Texting, calling, messaging, and at the same time allowing her plenty of breathing room, I never smothered her with affection like I'd done in the past, she was never very receptive to that.

As our two year anniversary passed, I was as content with life as I'd ever been. I'd worked hard to rebuild the trust between Bex and I, everything seemed like a dream, I was saving a lot of money very much in anticipation of our meet this summer, which we planned to be longer and far grander than the last. I was doing well in school, life was as perfect as I could hope for. The past seemed a distant, insignificant memory that couldn't touch us any longer.

Since April, Bex changed me so dramatically, she became the driving force in my life that allowed me gain more confidence and believe in myself. She is every reason why I became so happy and felt so fulfilled during that time. Without her temperance, guidance, and faith in me, I would never have made it this far.

Then last Sunday it all came crashing down. And now today the final nail has been driven into my coffin. I know a lot if not all of you have at least lost all respect for me, and as well you should have. I know some of you now hate me, or no longer consider me the friend you once did. No apologetic sincerity will ever be worth an ounce of forgiveness for what I've done. I had always feared my sins would return to visit me, and the cost is more than I can bear. There is no joy left in my life, but that is not a grievance, because I have no right to grieve. All that has transpired is no one's fault but my own. I can assure you I am not the weak man I once was, at least I wasn't until she left me, but I suppose it was inevitable. One way or another I was fated to this conclusion because of the horribly poor choices of my past.

I'm quite sure I will be the subject of much humiliating internet comedy long after I'm gone. I can't help that, and I probably deserve every bit of it. I'm sure somewhere in Canada, Channy and Ist are celebrating some sort of victory with alcohol and sex. I wish I could hate them, yet the only one to blame here ultimately is myself. Congratulations Channy, Ist; you won the war, I'm sure you feel your ban is well worth ruining your enemy's life.

I had thought of making a fresh start. Returning to the forum after a period of time, remaining friends with Bex, and all of you. But that no longer seems possible. So I hereby take my leave of the internet. You will likely never see or hear from me again. Personally if I were in the position of any of you my words would be 'good riddance', and I'm sure a fair few of you are thinking that.

I've made a lot of amazing friends over the past few years I've been with ACF, FCF, and everywhere in between. I will miss a lot of you truly, and wish you all the best in life. Alex, Sheena, Adri, Aaron, Brent, Christian, Dustin, Scott, Tasha, Chris, Reg, Joe, Alexx, Greg, Rose, Dave, Kelsey, and anyone else I've carelessly forgotten in my crushed mental state. For what it's worth, I considered you all friends, whether I knew you irl or not, and I'm sorry this is how we must part ways.

Above all else I will miss Bex. The light and love of my life. You are honestly the most beautiful person on this planet in my eyes, in every way. You are so talented, funny, intelligent, mature, faithful, sensible, and the ensuing list would make this post impossible to complete were I to enumerate every detail. You showed me an honest and true love I'm sure I will never find again, and I don't want to, unless it's with you. If I could turn back time I would loop these past two years with you for all eternity, of course doing many things differently, correcting errors of judgment and character I should have never made. You are truly the most amazing person I've ever met. If my heart is ever to be mended again, it will only be done through your love, which I do not deserve and am sure never to experience again. I'm sorry for every bit of pain I've caused you, I was certainly not the best man a girl could want, although I tried, I tried so hard. If there's any consolation I can find now, it's that you follow your heart and dreams, and find the happiness I found when I was with you. I still hold true to that solemn vow. I know this romantic rhetoric doesn't amount to much in your eyes, nor anyone's, but it's just what I need to say if I'm ever going to make peace with myself, and everyone who bothers to read all of this.

This is my final goodbye. I've deleted msn and skype from my computer, and stripped my facebook account. I've asked a friend to forward a request that my account here be banned and if possible, deleted. Farewell everyone.

Goodbye Bex. I love you, I always have and always will.




— Clearly this man has very little to do with his life now that he lost the one thing that made him cling to the internets so desperately.
 

SuN

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Kirtaner is a Canadian anime dork and pedophile. Online Kirt has also been identified as a piece of shit faggot who runs 420chan, and in real life as Aubrey a hopeless drug addict.

Kirtaner's only notable actions in life revolve around "ironically" being gay, possessing/creating child porn, giving buttplugs to jailbait on a first date, and generally being a stupid turd. One of the most memorable things he did was abuse drugs and then impersonate mmmmmmmmmmmm in a live showing for his pedophile anime irc buddy Shii. Immediately after this he also took pictures of himself sniffing his fingers.

When not taking pictures of himself being wacky and ironic and tearing his asshole apart, he can be found posting in his livejournal (LONG GONE NOW) about abusing drugs and subsequently having sex with any passing bodily orifice. He doesn't seem to mention, however, that he still lives with his mom, and remains unemployed, hence the frequent calls for donations on 420chan.

Recently, Kirtaner has hooked up with Yoko-ono esque Sparto. It's the standard internet relationship: friendless-in-IRL, personality-dysfunctional attention whore sluts it up for nerds to get more of the delicious attention she so desperately craves; attention whore latches on to powerful e-penis wielder; attention whore receives modship of shitty website; attention whore becomes e-penis wielder's "gf 4evr". The relationship is scheduled to end in a few months the same way they always do: attention whore turns out to be a dude, e-penis wielder bans attention whore forever, we pretend like it never happened. So far, however, they've somehow managed to stay together for 2 years.

Internet presence

When not having his pipes cleaned out by black dicks, he is usually posting on his message board "420chan", a haven for maladjusted pedo anime faggots like himself and Marshall Banana. Prior to this, he ran the website spyderlake which in turn illegally ran a server for the gook mmorpg Ragnarok Online because he really fucking loves Japan and is apparently suffering from a very special type of AIDS that makes him forget that Rag is from Korea. Srsly

Due to the stupid cunt leaving his image directories open, child porn (The homo claims it was actually xenogears loli but no one believes him because he is Kirtaner) was found on his webspace and he was banned from Something Awful after forum members led a crusade to get him and his retarded partner in crime Marshall Banana permabanned. This act was somehow a crushing blow to his self-esteem that turned him into a bigger introvert. In addition to this, there were pictures of him kissing men at anime conventions, proudly displaying his malnourished and horrifyingly thin frame, and the aforementioned pictures of him "ironically" jamming his hands into his goddamn asshole.

It has been alleged that Kirtaner had asked other goons to choke him during SA meetups. He also tends to do various things with his ass during Stickam sessions, such as shoving a bottle in it, pulling it wide open a la mmmmmmmmmmmm, or trying to replicate loopback.jpg.

Kirtaner was recently outed as abysmally shit SA poster Chroanopol, and was permabanned. He was recently outed again as 'terrakin' (an anagram of Kirtaner) and booted yet again.

Kirtaner is also a former member of the BatJew forums. He was frequently mocked there just as he is mocked across the internets. Kirtypoo fanboys claim Kirtaner is a very good friend of Moot's and W.T. Snacks as well as one of the very first channers, even stealing the original 30get on 4chan when it was first started up.

Kirtaner_in_a_skirt.jpg
 

SuN

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<@weev> ajt: why the fuck would you want to pay for some stupid fucking framework
<@weev> i thought people were paying for 0day
<@weev> isnt core like 70k?
<@weev> or something ludicrious?
<@ajt> because it is really the only way to fly when people are paying for it
<@ajt> it logs and the payload it sends are beyond repraoch
<@ajt> its ability to pivot is awesome
<@ajt> and all of the exploits are tested pretty well.
<@ajt> consider that core costs 25K
<@weev> oh
<@weev> thats not so bad
<@weev> ioerror said it cost 70k
<@ajt> and after one or maybe two test, it is paid for
<@ajt> no
<@ajt> and 25 is for an unrestricted license
<@weev> that guy is a stupid fucking blogger wannabe tho
<@ajt> which guy?
<@weev> jacob applebaum
<@ajt> yes he is a stupid faggot 4 sure
<@ajt> but if you are doing pentests for banks and utilities and shit they do not want to be burned by 0day anyways
<@ajt> 9 times out of 10 they find it too unrealistic
<@ajt> "WHO AHS 0DAY>!!>>! NO ONE THAT IS WHO"
<@weev> loool
<@weev> of course, noone audits software
< vxp> :D
<@ajt> no
<@ajt> weev, how are you going to get the source code?
<@ajt> you are talking crazy
<@ajt> this isnt a movie, weev
<@weev> this directory full of proprietary sources in my homedir does not exist
<@ajt> this is the real world
<@ajt> there arent people running around the internet breaking into machines using exploits that are unknown
<@weev> of course not
<@weev> the internet is a very friendly place
<@weev> in fact i think we should rename it the snugglenet to emphasize its friendliness and safety
<@ajt> SNUGGLENET
-%- ajt changed the topic of #ed to: Welcome to ED. The best site on the snugglenet!
< vxp> haha
<@ajt> yes yes
< vxp> NO H8 ON SNUGGLENET
<@ajt> I agree
 

SuN

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A Ronald Reagan is a natural disaster that is believed to occur when a dumbass Hollywood reject decides that the intellectual strain associated with being a B-list celebrity is unbearable and instead devotes himself to a career in politics, creating a drone cult consisting of devoted followers who share in his desire to fuck up the world Reagan followers are rightly quick to call out Obamabots for their sad devotion to a typical politician. The problem arises when they fail to realize the irony in criticizing Obama while giving head to Reagan.

Serving as the Führer and the 40th President of the United States, or Fourth Reich, Reagan is fondly remembered for being at least 100 feet tall. He was a hideous old fart with a disgusting, leaking bowel system. He served two terms, from 1980 to 1984, and then again from 1984 to bedtime. He is widely remembered by conservatives and Republicans to be an hero. However, the poor people did not remember him at all, because he starved them to death.

Thanks to his sponsorship of Terrorism, Ronald Reagan single-handedly destroyed communism forever, ensured the prosperity of the filthy rich, and saved Jesus from the Jews. Born Herschel Jewlowitz III, to loving father Herschel II, a fucking kike pimp, and Marylin "I takes it how you wants to give it to me" Kykesavage. His father was a ruthless pimp, and a stern father. Ronnie would say in his biography, "After a while I got used to the merciless anal poundings perpetrated by my father. But the hemorrhoids and emotional scars remain."

There is so much badass in Ronald Reagan, noone can deny. He is the Arnold Schwarzenegger of presidency, but cooler.

In his early years, Reagan was an underground porn actor. His best-known film is probably Godless Homo 3, the story of a young man receiving a massive semen communion for a full 120 minutes. In the 1970s, Reagan successfully ran for Governor of California. At this point his tits had grown to a full C. After winning, he allegedly stated "I've seen more than most people my age. I need to shave my boobs every day, but boy does it pay off. Now where did that child prostitute go?"

Because of his racist beliefs, Reagan wanted to build nuclear space weapons to kill non-Aryans on the moon. His scheme was hindered by hippie perverts. He also tried to kill non-whites by eliminating welfare, as he knew that only black people need it because they are so goddamn poor.

In late 1980, he invented AIDS for the lulz. He once dressed as an aardvark and plucked a banjo in an abandoned laundromat.

He is universally recognized as an innovator in American politics, having made being blatantly racist, sexist, and indifferent to basic human rights an acceptable national platform.

He was subject of an assassination attempt by a four year old asshole in 1981, after which he was clinically dead for about two weeks. Kept alive with melted goose pumped into his veins, he was finally revived by radioactive wisdom sucked from Hitler's ancient, preserved cervix.

After his 1988 resignation, Reagan regressed into total senility, to the entertainment of his close relatives. He was often made to believe his name was "Pure AIDS", "Smelly Balls" or "Freddie Mercury's Big Plump Slut". They also duped him into eating non-Aryan children, something his deeply racist pre-Alzheimer self never would have agreed to.

He initiated unprecedentedly severe drug enforcement laws, which said that you could be given a life sentence in 45 states if you were found with so much as a hemp seed in your pocket. These laws were only enforced in the event that the involved person was nigra. Whites were set free if arrested at all, unless they were poor, in which case they are considered nigra anyway and treated accordingly. The plan was officially called "Operation Get Darky". He also made sure that the private prisons made lots of money by having the CIA import enormous amounts of drugs from whatever foreign country they were raping and pillaging at the time. The drugs were then pushed by the government into the American cities that Reagan had deliberately impoverished, as an attractive menace to people who are struggling to so much as buy bread. Some might call this federal entrapment, others praised the actions as strong leadership from a president who was “cleaning up” the country (most Reagan supporters were just happy that he was able to start putting cupcakeers in prison where they belong). Supplying both the problem and the solution in one this way was considered very innovative for the time, and served as a model for all subsequent administrations.

In the summer of 2004, President Reagan passed away after choking on a bukkake smorgasbord provided by David Hasselhof, Ann Coulter, Dick Cheney, Donald Rumsfeld, and several others. A good way to troll conservatives is to tell them about the party you had when he died. He is today worshiped by many necrophiliacs as the Greatest President ever and/or God.
Ronald Reagan was a member of the Democratic Party until he caught a nasty case of Alzheimer's Disease from the Cult of the Dead Cow. As a result, he switched to the Republican Party. It wasn't until after he was done being President that his affliction was revealed. Few public sightings of Reagan occurred after that, but it is said that he increasingly resembled a bewildered and confused cross between Marmaduke and The Crypt Keeper.

It was also suggested that Margaret Thatcher was responsible for his demise though poisnoning, being pissed he'd chosen Nancy. Maggie (Hatchet Face) ought to have shaved her hairy tits before trying to seduce him

INCIDENCE OF ORGASMS IN FANTASIES OF SEXUAL INTERCOURSE WITH RONALD REAGAN. Patients were provided with assembly kit photographs of sexual partners during intercourse. In each case Reagan’s face was superimposed upon the original partner. Vaginal intercourse with "Reagan" proved uniformly disappointing, producing orgasm in 2% of subjects.

Axillary, buccal, navel, aural, and orbital modes produced proximal erections. The preferred mode of entry overwhelmingly proved to be the rectal. After a preliminary course in anatomy it was found that the caecum and transverse colon also provided excellent sites for excitation. In an extreme 12% of cases, the simulated anus of post-colostomy surgery generated spontaneous orgasm in 98% of penetrations. Multiple-track cine-films were constructed of "Reagan" in intercourse during (a) campaign speeches, (b) rear-end auto collisions with one and three year model changes, (c) with rear exhaust assemblies...

SEXUAL FANTASIES IN CONNECTION WITH RONALD REAGAN. The genitalia of the Presidential contender exercised a continuing fascination. A series of imaginary genitalia were constructed using (a) the mouth parts of Jacqueline Kennedy, (b) a Cadillac (with some Ds thrown on that bitch for good measure,) (c) the assembly kid prepuce of President Johnson...In 89% of cases, the constructed genitalia generated a high incidence of self-induced orgasm. Tests indicate the masturbatory nature of the Presidential contenders posture. Dolls consisting of plastic models of Reagan’s alternate genitalia were found to have a disturbing effect on deprived children.


—Dr. J Graham Ballard
 

SuN

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コモンズには様々な画像や映像などのメディア素材がアップロードされています。この中には日本の法律を遵守する立場から見ると問題となるものも多くあり、日本語版ウィキペディアでそれらの素材を使用する際は注意が必要な場合があります。ただ、これらコモンズに集められている素材は各言語版の各記事の単なる飾りの為に集められているのではありません。それらひとつひとつが書物等では手に入らないものやあるいは記事内の文章を客観的に確認出来ない状況にある場合に各記事の情報元を証明する一つの手段として掲示しているのです。特に著名性が低いがある特定の分野において特筆性がある記事の場合はこの画像による資料掲示という手段は大きな意義があります。それほど著名性の無い公園あるいは史跡等の記事の場合、その参照元の資料が少ないという場合が多く、よってそれら各史跡等にある説明板の画像は記事の信頼性を高める為の素材として非常に重要なものとなります。ただ、日本の法律に抵触する可能性というのが残ります。よって説明板などの場合はコモンズにその画像をアップロードし、任意の記事へその情報参照元がコモンズのメディア内にあることを示す程度で良いと思います。--Corpse Reviver (talk) 05:24, 7 March 2009 (UTC)
 

SuN

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The Club des Hashischins was a Parisian group dedicated to the exploration of drug-induced experiences, notably with hashish.

It was active from about 1844 to 1849 and counted the literary and intellectual elite of Paris among its members, including Dr. Jacques-Joseph Moreau, Théophile Gautier, Charles Baudelaire, Gérard de Nerval, Eugène Delacroix and Alexandre Dumas, père. Monthly "séances" were held at the Hôtel de Lauzun (at that time: Hôtel Pimodan) on the Île Saint-Louis.

Gautier wrote about the club in an article entitled "Le Club des Hachichin" published in the Revue des Deux Mondes in February 1846, recounting his recent visit. While he is often cited as the founder of the club, in the article his says he was attending their séances for the first time that evening and made clear that others were sharing a familiar experience with him.

*In actuality, several of the members of the Club des Hashischins did not participate in the use of hash. Gautier consumed the drug on several occasions but not as frequently as we are led to believe by today's "historians." Baudelaire is said to have never used hash because he was afraid to "lose his willpower." This is something that I believe to be very indicative of Baudelaire's personality, and entirely in keeping with the image of him that I have held since I first read (and fell in love with) Les Maladives. NOTE: I have found J. G. Palache's Gautier and the Romantics to be, at times, an extremely accurate, albeit somewhat misguided, portrayal of Gautier and his contemporaries. Although Palache was not widely known for this biography, which I attribute to slightly poor organization and overall immaturity in development, it was an entertaining read, as long as you know something about the literary scene of the time- otherwise it loses some of its weight. It is also no longer relevant as most of its information can be derived from more reliable sources and I would not necessarily praise its use for factual papers or studies. I would suggest it for those of you who enjoy the work of the era and simply have a love of reading, as I do, and therefore can appreciate it as not only a historical account but also for its endearing anecdotes.
 

SuN

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Lysergic acid diethylamide, abbreviated LSD or LSD-25, also known as lysergide and colloquially as acid, is a semisynthetic psychedelic drug of the ergoline and tryptamine families. LSD is non-addictive, non-toxic, and is well known for its psychological effects which can include altered thinking processes, closed and open eye visuals, synaesthesia, a sense of time distortion, ego death and spiritual experiences, as well as for its key role in 1960s counterculture. It is used mainly by psychonauts as an entheogen, recreational drug and as an agent in psychedelic therapy.

LSD was first synthesized by Albert Hofmann in 1938 from ergot, a grain fungus that typically grows on rye. The short form LSD comes from its early code name LSD-25, which is an abbreviation for the German "Lysergsäure-diethylamid" followed by a sequential number. LSD is sensitive to oxygen, ultraviolet light, and chlorine, especially in solution, though its potency may last for years if it is stored away from light and moisture at low temperature. In pure form it is a colorless, odorless, and mildly bitter solid. LSD is typically delivered orally, usually on a substrate such as absorbent blotter paper, a sugar cube, or gelatin. In its liquid form, it can also be administered by intramuscular or intravenous injection. LSD is very potent, with 20–30 µg (micrograms) being the threshold dose.

Introduced by Sandoz Laboratories, with trade-name Delysid, as a drug with various psychiatric uses in 1947, LSD quickly became a therapeutic agent that appeared to show great promise. However, the emerging recreational use of the drug by youth culture in the Western world during the 1960s led to a political firestorm that resulted in its prohibition. A number of organizations—including the Beckley Foundation, MAPS, Heffter Research Institute and the Albert Hofmann Foundation—exist to fund, encourage and coordinate research into its medicinal uses.

LSD is an ergoline derivative. It is commonly synthesised by reacting diethylamine with an activated form of lysergic acid. Activating reagents include phosphoryl chloride[9] and peptide coupling reagents. Lysergic acid is made by alkaline hydrolysis of lysergamides like ergotamine, a substance derived from the ergot fungus on rye, or from ergine (lysergic acid amide, LSA), a compound that is found in morning glory (Ipomoea tricolor) and hawaiian baby woodrose (Argyreia nervosa) seeds.

LSD is a chiral compound with two stereocenters at the carbon atoms C-5 and C-8, so that theoretically four different optical isomers of LSD could exist. LSD, also called (+)-D-LSD, has the absolute configuration (5R,8R). The C-5 isomers of lysergamides do not exist in nature and are not formed during the synthesis from D-lysergic acid. Retrosynthetically, the C-5 chiral center could be analysed as having the same chirality of the alpha carbon of the biological amino acid L-tryptophan, the precursor to all biosynthetic ergoline compounds.

However, LSD and iso-LSD, the two C-8 isomers, rapidly interconvert in the presence of base, as the alpha proton is especially acidic and can be removed to catayse conversion to enol or enolate form. The enolate and enol forms are stabilised by resonance interactions with the aromatic indole ring. Non-psychoactive iso-LSD which has formed during the synthesis can be removed by chromatography and can be isomerized to LSD.

Though acid nominally also activates a carbonyl compound's enol form, LSD has a tertiary amine group and enamine-like system, both which compete as basic sites for protonation. Acid also triggers unwanted isomerisation of the ring-adjacent double bond via tertiary carbocation intermediate. (This isomerisation also eliminates the sensitive chiral center next to the tertiary amino group.) The carbocation is especially resonance-stabilised, as the carbocation position is next to an electron-donating indole ring. The presence of nucleophiles triggers a rich array of degradation pathways in the presence of acid.

A totally pure salt of LSD will emit small flashes of white light when shaken in the dark. LSD is strongly fluorescent and will glow bluish-white under UV light.

"LSD," writes the chemist Alexander Shulgin, "is an unusually fragile molecule." It is stable for indefinite time if stored as a solid salt or dissolved in water, at low temperature and protected from air and light exposure.

LSD has two sensitive chiral tertiary protons at the C5 and C8 positions that are prone to racemisation. The C8 proton is more labile due to the electron-withdrawing carboxamide attachment, but removal of the chiral proton at the C5 position (which actually was once also an alpha proton of the parent molecule tryptophan) is assisted by the inductively-withdrawing nitrogen and pi electron delocalisation with the indole ring.

LSD also has enamine-type reactivity because of the electron-donating effects of the indole ring. Because of this, chlorine destroys LSD molecules on contact; even though chlorinated tap water typically contains only a slight amount of chlorine, because a typical LSD solution only contains a small amount of LSD, dissolving LSD in tap water is likely to completely eliminate the substance. The double bond between the 8-position and the aromatic ring, being conjugated with the indole ring, is susceptible to nucleophilic attacks by water or alcohol, especially in the presence of light. LSD often converts to "lumi-LSD", which is totally inactive in human beings (to the best of current knowledge).

A controlled study was undertaken to determine the stability of LSD in pooled urine samples. The concentrations of LSD in urine samples were followed over time at various temperatures, in different types of storage containers, at various exposures to different wavelengths of light, and at varying pH values. These studies demonstrated no significant loss in LSD concentration at 25 °C for up to four weeks. After four weeks of incubation, a 30% loss in LSD concentration at 37 °C and up to a 40% at 45 °C were observed. Urine fortified with LSD and stored in amber glass or nontransparent polyethylene containers showed no change in concentration under any light conditions. Stability of LSD in transparent containers under light was dependent on the distance between the light source and the samples, the wavelength of light, exposure time, and the intensity of light. After prolonged exposure to heat in alkaline pH conditions, 10 to 15% of the parent LSD epimerized to iso-LSD. Under acidic conditions, less than 5% of the LSD was converted to iso-LSD. It was also demonstrated that trace amounts of metal ions in buffer or urine could catalyze the decomposition of LSD and that this process can be avoided by the addition of EDTA.

A single dose of LSD may be between 100 and 500 micrograms — an amount roughly equal to one-tenth the mass of a grain of sand. Threshold effects can be felt with as little as 25 micrograms of LSD. Dosages of LSD are measured in micrograms (µg), or millionths of a gram. By comparison, dosages of most drugs, both recreational and medicinal, are measured in milligrams (mg), or thousandths of a gram. For example, an active dose of mescaline, roughly 0.2 to 0.5g, has effects comparable to 100 µg or less of LSD.

Typical doses in the 1960s ranged from 200 to 1000 µg while street samples of the 1970s contained 30 to 300 µg. By the 1980s, the amount had reduced to between 100 to 125 µg, lowering more in the 1990s to the 20–80 µg range.

Estimates for the lethal dosage (LD50) of LSD range from between 200 µg/kg to more than 1 mg/kg of human body mass, though most sources report that there are no known human cases of such an overdose. Other sources note one report of a suspected fatal overdose of LSD occurring in November 1975 in Kentucky in which there were indications that ~1/3 of a gram (320 mg or 320,000 µg) had been injected intravenously. (This is a very extraordinary amount, particularly when compared to the average LSD dosage of ~100 µg). Experiments with LSD have also been done on animals; in 1962, an elephant named Tusko died shortly after being injected with 297 mg, but whether the LSD was the cause of his death is controversial.

LSD was first synthesized on November 16, 1938 by Swiss chemist Dr. Albert Hofmann at the Sandoz Laboratories in Basel, Switzerland as part of a large research program searching for medically useful ergot alkaloid derivatives. LSD's psychedelic properties were discovered 5 years later when Hofmann accidentally ingested an unknown quantity of the chemical. The first intentional ingestion of LSD occurred on April 19, 1943, when Dr. Hofmann ingested 250 µg of LSD. He hypothesized this would be a threshold dose based on the dosages of other ergot alkaloids. Hofmann found the effects to be much stronger than he anticipated. Sandoz Laboratories introduced LSD as a psychiatric drug in 1947.

Beginning in the 1950s the US Central Intelligence Agency began a research program code named Project MKULTRA. Experiments included administering LSD to CIA employees, military personnel, doctors, other government agents, prostitutes, mentally ill patients, and members of the general public in order to study their reactions, usually without the subject's knowledge. The project was revealed in the US congressional Rockefeller Commission report in 1975.

In 1963 the Sandoz patents expired on LSD. Also in 1963, the US Food and Drug Administration classified LSD as an Investigational New Drug, which meant new restrictions on medical and scientific use. Several figures, including Aldous Huxley, Timothy Leary, and Al Hubbard, began to advocate the use of LSD. LSD became central to the counterculture of the 1960s. On October 24, 1968, possession of LSD was made illegal in the United States. The last FDA approved human study with LSD, for use in dying cancer patients, ended in 1980. Legally approved and regulated psychiatric use of LSD continued in Switzerland until 1993. Today, medical research is resuming around the world.

Effects Physical

LSD reliably causes pupil dilation, reduced appetite, and wakefulness. Other physical reactions to LSD are highly variable and nonspecific, and some of these reactions may be secondary to the psychological effects of LSD. The following symptoms have been reported: numbness, weakness, nausea, hypothermia or hyperthermia (decreased or increased body temperature), elevated blood sugar, goose bumps, increase in heart rate, jaw clenching, perspiration, saliva production, mucus production, sleeplessness, hyperreflexia, and tremors. Uterine contractions have been reported in animals. Some users report a strong metallic taste for the duration of the effects.

LSD is not considered addictive by the medical community.Rapid tolerance build-up prevents regular use, and there is cross-tolerance shown between LSD, mescaline and psilocybin. This tolerance diminishes after a few days without use and is probably caused by downregulation of 5-HT2A receptors in the brain.

Psychological

LSD's psychological effects (colloquially called a "trip") vary greatly from person to person, depending on factors such as previous experiences, state of mind and environment, as well as dose strength. They also vary from one trip to another, and even as time passes during a single trip. An LSD trip can have long-term psychoemotional effects; some users cite the LSD experience as causing significant changes in their personality and life perspective. Widely different effects emerge based on what Timothy Leary called set and setting; the "set" being the general mindset of the user, and the "setting" being the physical and social environment in which the drug's effects are experienced.

Some psychological effects may include an experience of radiant colors, objects and surfaces appearing to ripple or "breathe," colored patterns behind the eyes, a sense of time distorting (time seems to be stretching, repeating itself, changing speed or stopping), crawling geometric patterns overlaying walls and other objects, morphing objects, a sense that one's thoughts are spiraling into themselves, loss of a sense of identity or the ego (known as "ego death"), and other powerful psycho-physical reactions. Many users experience a dissolution between themselves and the "outside world". This unitive quality may play a role in the spiritual and religious aspects of LSD. The drug sometimes leads to disintegration or restructuring of the user's historical personality and creates a mental state that some users report allows them to have more choice regarding the nature of their own personality.

If the user is in a hostile or otherwise unsettling environment, or is not mentally prepared for the powerful distortions in perception and thought that the drug causes, effects are more likely to be unpleasant than if he or she is in a comfortable environment and has a relaxed, balanced and open mindset.

Sensory / perception

LSD causes expansion and an altered experience of senses, emotions, memories, time, and awareness for 6 to 14 hours, depending on dosage and tolerance. Generally beginning within thirty to ninety minutes after ingestion, the user may experience anything from subtle changes in perception to overwhelming cognitive shifts. Changes in auditory and visual perception are typical. Visual effects include the illusion of movement of static surfaces ("walls breathing"), after image-like trails of moving objects ("tracers"), the appearance of moving colored geometric patterns (especially with closed eyes), an intensification of colors and brightness ("sparkling"), new textures on objects, blurred vision, and shape suggestibility. Users commonly report that the inanimate world appears to animate in an unexplained way; for instance, objects that are static in three dimensions can seem to be moving relative to one or more additional spatial dimensions. Many of the basic visual effects resemble the phosphenes seen after applying pressure to the eye and have also been studied under the name "form constants". The auditory effects of LSD may include echo-like distortions of sounds, changes in ability to discern concurrent auditory stimuli, and a general intensification of the experience of music. Higher doses often cause intense and fundamental distortions of sensory perception such as synaesthesia, the experience of additional spatial or temporal dimensions, and temporary dissociation.

Potential use

LSD has been used in psychiatry for its perceived therapeutic value, in the treatment of alcoholism, pain and cluster headache relief, for spiritual purposes, and to enhance creativity. However, government organizations like the United States Drug Enforcement Administration maintain that LSD "produces no aphrodisiac effects, does not increase creativity, has no lasting positive effect in treating alcoholics or criminals, does not produce a 'model psychosis', and does not generate immediate personality change."

Psychotherapy

In the 1950s and 1960s LSD was used in psychiatry to enhance psychotherapy. Some psychiatrists believed LSD was especially useful at helping patients to "unblock" repressed subconscious material through other psychotherapeutic methods,[33] and also for treating alcoholism. One study concluded, "The root of the therapeutic value of the LSD experience is its potential for producing self-acceptance and self-surrender," presumably by forcing the user to face issues and problems in that individual's psyche.

In December 1968, a survey was made of all 74 UK doctors who had used LSD in humans, 73 replied, 1 had moved overseas and was unavailable. Of the 73 replies, the majority of UK doctors with clinical experience with LSD felt that LSD was effective and had acceptable safety: 41 (56%) continued with clinical use of LSD, 11 (15%) had stopped because of retirement or other extraneous reasons, 9 (12%) had stopped because they found LSD ineffective, and 5 (7%) had stopped because they felt LSD was too dangerous.

Alcoholism

Some studies in the 1950s that used LSD to treat alcoholism professed a 50% success rate, five times higher than estimates near 10% for Alcoholics Anonymous. These studies were criticized for methodological flaws, and different groups had inconsistent results. Mangini's 1998 paper reviewed this history. She concluded that the efficacy of LSD in treating alcoholism remains an open question.

Pain

LSD was studied in the 1960s by Eric Kast as an analgesic for serious and chronic pain caused by cancer or other major trauma. Even at low (sub-psychedelic) dosages, it was found to be at least as effective as traditional opiates, while being much longer lasting pain reduction (lasting as long as a week after peak effects had subsided). Kast attributed this effect to a decrease in anxiety. This reported effect is being tested (though not using LSD) in an ongoing (as of 2006) study of the effects of the psychedelic tryptamine psilocybin on anxiety in terminal cancer patients.

Cluster headaches

LSD has been used as a treatment for cluster headaches, an uncommon but extremely painful disorder. Researcher Peter Goadsby describes the headaches as "worse than natural childbirth or even amputation without anesthetic." Although the phenomenon has not been formally investigated, case reports indicate that LSD and psilocybin can reduce cluster pain and also interrupt the cluster-headache cycle, preventing future headaches from occurring. Currently existing treatments include various ergolines, among other chemicals, so LSD's efficacy may not be surprising. A dose-response study testing the effectiveness of both LSD and psilocybin was planned at McLean Hospital, although the current status of this project is unclear. A 2006 study by McLean researchers interviewed 53 cluster-headache sufferers who treated themselves with either LSD or psilocybin, finding that a majority of the users of either drug reported beneficial effects. Unlike use of LSD or MDMA in psychotherapy, this research involves non-psychological effects and often sub-psychedelic dosages.

Spiritual

LSD is considered an entheogen because it can catalyze intense spiritual experiences, during which users may feel they have come into contact with a greater spiritual or cosmic order. Users claim to experience lucid sensations where they have "out of body" experiences. Some users report insights into the way the mind works, and some experience permanent shifts in their life perspective. Some users consider LSD a religious sacrament, or a powerful tool for access to the divine. Dr. Stanislav Grof has written that religious and mystical experiences observed during LSD sessions appear to be phenomenologically indistinguishable from similar descriptions in the sacred scriptures of the great religions of the world and the secret mystical texts of ancient civilizations.

Creativity

In the 1950s and 1960s, psychiatrists like Oscar Janiger explored the potential effect of LSD on creativity. Experimental studies attempted to measure the effect of LSD on creative activity and aesthetic appreciation. One patient of Dr. Janiger, bipolar and alcoholic artist Frank Murdoch, was given a controlled, experimental dose of LSD for several months in an attempt to cure his late stage alcoholism. Janiger had Murdoch paint still-lives both on and off LSD, including a Kachina doll (that he reportedly had 70 other patients also paint). The artists/ patients produced some 250 paintings and drawings after ingesting LSD).
 

SuN

.:~**~.~**~.~**~:.
Dysthymia (pronounced /dɪsˈθaɪmiə/) is a chronic mood disorder that falls within the depression spectrum, the opposite of hyperthymia. It is considered a chronic depression, but with less severity than major depressive disorder. This disorder tends to be a chronic, long-lasting illness.[1]

Dysthymia is a type of low-grade depression. Harvard Health Publications states that, "the Greek word dysthymia means 'bad state of mind' or 'ill humour'. As one of the two chief forms of clinical depression, it usually has fewer or less serious symptoms than major depression but lasts longer."[2] Harvard Health Publications also says, "at least three-quarters of patients with dysthymia also have a chronic physical illness or another psychiatric disorder such as one of the anxiety disorders, drug addiction, or alcoholism".[2] The Primary Care Journal says that dysthymia "affects approximately three percent of the population and is associated with significant functional impairment".[citation needed] Harvard Health Publications says: "The rate of depression in the families of people with dysthymia is as high as fifty percent for the early-onset form of the disorder. [...] Most people with dysthymia can't tell for sure when they first became depressed".[2]

Dysthymia is a chronic long-lasting form of depression sharing many characteristic symptoms of major depressive disorder (in the form of the melancholic depression subtype). These symptoms tend to be less severe but do fluctuate in intensity.[3] To be diagnosed, an adult must experience 2 or more of the following symptoms for at least two years:[4]

* Feelings of hopelessness
* Insomnia or hypersomnia
* Poor concentration or difficulty making decisions
* Low energy or fatigue
* Low self-esteem
* Poor appetite or overeating.
* Irritability [1]

Symptoms exclude "manic, hypomanic or mixed episodes commonly associated with bipolar disorder".[5][6] (If a person experience these episodes they may suffer from cyclothymia.)

People with dysthymia have a greater-than-average chance of developing major depression. Fluctuating symptoms intensity can trigger a full-blown episode of major depression. This situation is sometimes called "double depression"[7] because the intense episode exists with the usual feelings of low mood.

As dysthymia is a chronic disorder, a person may often experience symptoms for many years before it is diagnosed, if diagnosis occurs at all. As a result, he or she tends to believe that depression is a part of their character. This, subsequently, may lead sufferers not to even discuss their symptoms with doctors, family members or friends.

Dysthymia, like major depression, tends to run in families. It is two to three times more common in women than in men[citation needed]. Some sufferers describe being under chronic stress. When treating diagnosed individuals, it is often difficult to tell whether they are under unusually high environmental stress or if the dysthymia causes them to be more psychologically stressed in a standard environment.

The Diagnostic and Statistical Manual of Mental Disorders (DSM), published by the American Psychiatric Association, characterizes dysthymic disorder.[8] The essential symptom involves the individual feeling depressed for the majority of days and parts of the day for at least two years. Low energy, disturbances in sleep or in appetite, and low self-esteem typically contribute to the clinical picture as well. Sufferers have often experienced dysthymia for many years before it is diagnosed. People around them come to believe that the sufferer is 'just a moody person'. Note the following diagnostic criteria:[1]

1. During a majority of days for two years or more, the adult patient reports depressed mood or appears depressed to others for most of the day.
2. When depressed, the patient has two or more of:
1. decreased or increased appetite
2. decreased or increased sleep (insomnia or hypersomnia)
3. Fatigue or low energy
4. Reduced self-esteem
5. Decreased concentration or problems making decisions
6. Feels hopeless or pessimistic
3. During this two-year period, the above symptoms are never absent longer than two consecutive months.
4. During the the first two years of this syndrome, the patient has not had a Major Depressive Episode.
5. The patient has not had any Manic, Hypomanic or Mixed Episodes.
6. The patient has never fulfilled criteria for cyclothymic disorder.
7. The depression does not exist only as part of a chronic psychosis (such as schizophrenia or delusional disorder).
8. The symptoms are often not directly caused by a medical illness or by substances, including drug abuse, or other medications.
9. The symptoms may cause significant problems or distress in social, work, academic, or other major areas of life functioning.[8]

People suffering from dysthymia are usually well capable of coping with their everyday lives (usually by following particular routines that provide certainty, i.e., some form of Obsessive–compulsive disorder (OCD), even if low-grade.).

In children and adolescents, mood can be irritable and duration must be at least one year, in contrast to two years needed for diagnosis in adults.
[edit] Treatments
[edit] Medications

If medication is deemed necessary, the most commonly prescribed anti-depressants for this disorder are the selective serotonin reuptake inhibitors (SSRIs), which include fluoxetine (Prozac), sertraline (Zoloft), escitalopram (Lexapro), paroxetine (Paxil), and citalopram (Celexa).[citation needed]. SSRIs are easy to take and relatively safe compared with older forms of anti-depressants.[9] Other new anti-depressants include bupropion (Wellbutrin), venlafaxine (Effexor), mirtazapine ('Remeron' OR ('Avanza' in Australia)), and duloxetine (Cymbalta).

Sometimes two different anti-depressant medications are prescribed together, or a physician may prescribe a mood stabilizer or anti-anxiety medication in combination with an anti-depressant.
[edit] Side effects of medications

Some side effects for SSRIs are "sexual dysfunction, nausea…diarrhea, sleepiness or insomnia, short-term memory loss and tremors". SSRIs can also cause suicidality and aggression in some cases.[citation needed] Some antidepressants are ineffective in patients[citation needed]. Older antidepressants, such as a tricyclic antidepressant or an MAOI can be tried in such cases. Tricyclic antidepressants are more effective but have worse side effects. Side effects for tricyclic antidepressants are "weight gain, dry mouth, blurry vision, sexual dysfunction, and low blood pressure".[citation needed]
[edit] Psychotherapy

Some evidence suggests the combination of medication and psychotherapy may result in the greatest improvement. The type of psychotherapy that will help depends on a number of factors, including the nature of any stressful events, the availability of family and other social support, and personal preference. Therapy should include education about depression. Support is essential. Cognitive behavioural therapy is designed to examine and help correct faulty, self-critical thought patterns and correct the cognitive distortions that persons with mood disorders commonly experience. Psychodynamic, insight-oriented or interpersonal psychotherapy can help a person sort out conflicts in important relationships or explore the history behind the symptoms.[citation needed]
[edit] Friends and family

Anecdotal evidence indicates that the subject's awareness that he/she forms an important part in the lives of the people familiar to him/her both near and far holds great promise in helping the subject to cope. Reminders are to be given daily and support given freely when asked for. Depression is a condition hard to convey in lucid terms because there does not need to be a determinable vector or cause. Friends and family are encouraged to be aware and accept that they don't need to understand in order to care.[citation needed]
[edit] See also

* Anhedonia, a symptom of dysthymia characterized by a decreased or absent ability to enjoy a sense of pleasure. This may also be a symptom of schizophrenia and/or clinical depression. In addition, this disorder can be caused by excessive use of amphetamines.
* Blunted affect, a symptom of PTSD, schizophrenia, and ASPD involving decreased or absent emotional response
* Atypical depression
* Major depressive disorder
 

SuN

.:~**~.~**~.~**~:.
He was a fast machine
He kept his motor clean
He was the best damn man I had ever seen
He had the sightless eyes
Telling me no lies
Knockin' me out with those jghjsgfjsdh thighs
Taking more than his share
Had me fighting for air
He told me to come but I was already there

'Cause the walls start shaking
The earth was quaking
My mind was aching
And we were making it and you -

Shook me all night long

Working double time
On the seduction line
He was one of a kind, he's just mine all mine
He wanted no applause
Just another course
Made a meal out of me and came back for more
Had to cool me down
To take another round
Now I'm back in the ring to take another swing

'Cause the walls were shaking
The earth was quaking
My mind was aching
And we were making it and you -

Shook me all night long!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!
 

SuN

.:~**~.~**~.~**~:.
[YOUTUBE]<object width="480" height="385"><param name="movie" value="http://www.youtube.com/v/Bomv-6CJSfM&hl=en_US&fs=1&color1=0x402061&color2=0x9461ca"></param><param name="allowFullScreen" value="true"></param><param name="allowscriptaccess" value="always"></param><embed src="http://www.youtube.com/v/Bomv-6CJSfM&hl=en_US&fs=1&color1=0x402061&color2=0x9461ca" type="application/x-shockwave-flash" allowscriptaccess="always" allowfullscreen="true" width="480" height="385"></embed></object>[/YOUTUBE]
 

SuN

.:~**~.~**~.~**~:.
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Seph

Retired Account
He was a fast machine
He kept his motor clean
He was the best damn man I had ever seen
He had the sightless eyes
Telling me no lies
Knockin' me out with those jghjsgfjsdh thighs
Taking more than his share
Had me fighting for air
He told me to come but I was already there

'Cause the walls start shaking
The earth was quaking
My mind was aching
And we were making it and you -

Shook me all night long

Working double time
On the seduction line
He was one of a kind, he's just mine all mine
He wanted no applause
Just another course
Made a meal out of me and came back for more
Had to cool me down
To take another round
Now I'm back in the ring to take another swing

'Cause the walls were shaking
The earth was quaking
My mind was aching
And we were making it and you -

Shook me all night long!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!

[YOUTUBE]_2XmLcnYSwQ[/YOUTUBE]
 
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